Webinar
We are pleased to welcome Prof. Milena Ivanova-Shivarova from the Department of Clinical Immunology, University Hospital Alexandrovska, Medical University Sofia, Bulgaria as our guest speaker for this webinar.
Previous studies showed that HLA-I genotype might differentially restrict JAK2V617F and CALRmut-driven oncogenesis and potentially explain the mutual exclusivity of the two mutations in myeloproliferative neoplasms (MPNs). The positive associations with HLA-I alleles suggest that HLA molecules could also mediate immunoedditing in MPN through interaction with KIRs.
To explore further this hypothesis, Prof. Ivanova-Shivarova and her team analysed allele level polymorphism of 8 KIR genes in MPN patients and healthy controls from the Bulgarian population. The associations observed suggest possible role of KIR alleles and KIR/ligand interactions in JAK2V617F and CALRmut driven MPN. These findings might have implications for better understanding the molecular mechanisms of mmunosurveillance and cancer invasion in MPN.
Attend the webinar and receive 0.15 continuing education credits (CECs).
Previous studies showed that HLA-I genotype might differentially restrict JAK2V617F and CALRmut-driven oncogenesis and potentially explain the mutual exclusivity of the two mutations in myeloproliferative neoplasms (MPNs). The positive associations with HLA-I alleles suggest that HLA molecules could also mediate immunoedditing in MPN through interaction with KIRs.
To explore further this hypothesis, Prof. Ivanova-Shivarova and her team analysed allele level polymorphism of 8 KIR genes in MPN patients and healthy controls from the Bulgarian population. The associations observed suggest possible role of KIR alleles and KIR/ligand interactions in JAK2V617F and CALRmut driven MPN. These findings might have implications for better understanding the molecular mechanisms of mmunosurveillance and cancer invasion in MPN.
Attend the webinar and receive 0.15 continuing education credits (CECs).
